A Retrospective Evaluation of the Management of Skin and Soft Tissue Infections in the Emergency Department


Skin and soft tissue infections (SSTI) are commonly managed in an Emergency Department (ED) setting.  Prior to the study, the outpatient intravenous (IV) antibiotic program at this major teaching hospital operated without any set protocol with respect to inclusion/exclusion criteria, treatment guidelines, and clinical pathways.  The objective of this study was to evaluate the management of SSTI in the ED, in order to determine the therapeutic implications of implementing a new treatment program.


Retrospective health record assessment for selected patients evaluating two 6-month treatment periods pre- and post-implementation of the new program.


Emergency Department of a major Canadian tertiary care teaching hospital.


Adult patients with SSTI (as diagnosed by emergency physicians and entered into the outpatient IV antibiotic program)


The pre-protocol management of SSTI was left at the discretion of the attending emergency physician.  The outpatient IV antibiotic program for SSTI utilized standardized protocols for both intravenous and oral therapy. Cefazolin 2 g IV every 24 hours with probenecid 1 g PO daily is the mainstay of therapy for simple cellulitis. Ceftriaxone 2 g IV every 24 hours was the therapy of choice for those with SSTI resulting from a cat, dog or human bite wound.  Oral (PO) regimens for step-down therapy were also included in the new program protocol for all SSTI.  The optimal treatment duration in the outpatient program was defined as less than or equal to 5 days.

Main Outcome Measures

The primary outcome was clinical treatment success defined as successful treatment in the outpatient program utilizing either

(i) PO therapy alone;

(ii) IV therapy alone; or

(iii) IV to PO stepdown

following resolution of infection. Secondary outcomes included compliance with the new protocol, overall treatment duration as well as appropriate use of recommended IV to PO step-down therapy.


428 patients (211 pre and 217 post) met our pre-defined inclusion criteria for the 12-month study period.  Simple cellulitis was the most common diagnosis between phases at 91% and 89%, respectively; and IV cefazolin and PO probenecid combination was the primary treatment regimen in both phases at 86% and 83%, respectively.  Overall treatment success was similar in both periods at 86% and 81% respectively.  Overall, compliance with the new outpatient program protocol was 96% with a significant improvement in the use of appropriate IV to PO therapy from 21% pre-protocol to 60% post-protocol.  Overall, 89% of patients were successfully treated in the ideal program duration of less than or equal to 5 days in following implementation of the new program.


The use of a standardized protocol for the outpatient management of SSTI from the ED has proven effective resulting in the prevention of many hospitalizations.

Latest Posts

Generic Viagra Online – Alternative for the purchase of Viagra.

The safe use of Kamagra Oral Jelly has been reviewed, recognized and used by many around the world.

The Viagra professional is an improved form of the original Viagra.

Sildenafil citrate is a generic medicine prescribed in cases of erectile dysfunction.

Caverta is available in 20 mg, 50 mg, and 100 mg oral pill

Sildenafil Over The Counter is the same Viagra brand (sildenafil citrate) that we all know, only now purchase is done from online pharmacy stores and shipping to your home with no need for medical prescription.

Silagra 100mg is effective in treating their erectile dysfunction problem.