• Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin versus Usual Care

    Original Citation Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs. usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Overall Study Question These investigators compared pravastatin to “usual care”

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  • Major outcomes in high-risk hypertensive patients randomized to ACE inhibitor or calcium channel blocker vs diuretic

    Original Citation The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs. diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002;288:2981-97. Overall Study Question These investigators compared chlorthalidone, amlodipine and lisinopril for the treatment

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  • Evidence-Based Snapshots

    Due to the popularity of the Evidence-Based Reviews of the Pharmacotherapy Literature section, we are enhancing this section with more of what our readers want.  JIP readers have told us that they want the “quick and dirty” on new trials that are reported virtually daily; Who was studied?  What were the results? What does it mean? Our

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  • Journal of Informed Pharmacotherapy 2003;12 (Jan – Mar)

    Editorial ALLHAT – So What? – James McCormack Email to the Editors Readers respond to the editorial “ALLHAT – So What?” Readers respond to “Pharmacist Scope of Practice: A Response to the 2002 ACP-ASIM Position Paper” Times have changed since pharmacists were primarily concerned with licking, sticking, counting and pouring pharmaceuticals.  A shift from a product-centered

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  • ALLHAT – So What?

    A month ago, results of the largest hypertension trial (ALLHAT) ever conducted were published. Researchers randomized over 30,000 patients with hypertension (plus one or more other risk factors) to chlorthalidone, amlodipine or lisinopril and followed them for approximately 5 years. Overall, this trial showed, at least for the primary outcome (combined fatal CHD or non-fatal

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  • Journal of  Informed Pharmacotherapy 2004;15 (Jan – Mar)

    Journal of Informed Pharmacotherapy 2004;15 (Jan – Mar)

    Editorial Canadian ePharmacies and the American Public: Mutualistic, Parasitic or Commensal Symbiosis? Things are heating up on the cross-border prescription front.  Hardly a day goes by without hearing from the opponents and proponents of those Canadian online pharmacies that sell prescription drugs to American consumers at lower prices than their United States (US) pharmacy counterparts. 

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